PDA: Drugs for Cancer

crosslinking platinum analogue, interferes with DNA replication killing the fastest proliferating cells. Side effects: nephrotoxicity

alkylating crosslinker, high doses: increased cytotoxicity & immunosuppression, lowdoses: antiangiogenic, immunostimulation. SE: nausea

glucocorticoid, steroid, SE: acne, depression, vomiting

inhibits BCR-ABL, used for CML and GIST (gastrointestinal stromal tumours), SE: nausea,diarrhoea

angiogenesis inhibitor, SE: flu-like syndrome (within 1-2hrs), fatigue, low blood count

inhibits dihydrofolate reductase immunosuppressant, SE: nausea, tiredness, low white cell counts, breakdown of skin in mouth, TERATOGENIC

targets tubulin, enhancing spindle formation -- prevents chromosomes form reaching metaphase -- blocks mitosis progression

glucocorticoid, immunosuppressant, SE: high blood glucose levels, fluid retention, depression, anxiety // Cushing's syndrome, osteoporosis

B cell depletor: antibody or fusion proteins that bind to CD20 on B-cells, increasing death by NK cells. SE: cardiac arrest, infections

pro-drug, anti-oestrogen, acts as an ER antagonist inhibiting transcription of oestrogen-responsive genes in tissues, blocks ErbB2/HER2.

angiogenesis inhibitor, inhibits production of TNF-alpha, IL6, IL10 and IL12, enhances production of IL2, IL4 and IL5. increases lymphocytes

monoclonal antibody, inhibits HER2, suppresses angiogenesis, SE: flu-like symptoms

mitotic spindle poison, binds to tubulin protein, stops the cell from separating chromosomes in metaphase. SE: chemo-induced p.neuropathy