GI Drugs

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77 cards·by s-bogusz

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Metoclopramide

Dopamine D2 receptor antagonist - prokinetic

Domperidone

Dopamine D2 receptor antagonist - prokinetic

Bethanichol

M3 receptor agonist - prokinetic for GERD and gastroparesis

Dicyclomine (Bentyl)

Anticholinergics - Antispasmodic for IBS

Hyoscyamine (Levsin)

Anticholinergic - Antispasmodic for IBS

Alosetron (Lotronex)

5-HT3 antagonist for IBS-D in women only

Lubiprostone (Amitiza)

CCA for IBS-C in non-pregnant women

Tegaserod (Zelnorm)

Serotonin 5-HT4 agonist - IBS-C in women. Heart caution

Sulfasalazine

5-ASA+sulfapyridine for IBD (azo)

Olsalazine

5-ASAx2 for IBD (azo)

Balsalazide

5-ASA+4-ABA for IBD (azo)

Pentasa

5-ASA/azo with timed release for IBD

Asacol/Apriso

5-ASA/azo with pH release for IBD

Lialda

5-ASA/azo with pH release for IBD

Rowasa

azo/5-ASA enema for IBD

Canasa

azo/5-ASA suppository for IBD

Prednisone/Prednisolone

Glucocorticoid for IBD

Budesonide

controlled release glucocorticoid for IBD and Crohns

Azothioprine

purine analog for UC and Crohn's

6-mercaptopurine

purine analog for UC and Crohn's

Methotrexate

antimetabolite for Crohn's

infliximab

TNF MAB for Crohn's and UC

adalimumab

TNF MAB for Crohn's

Certolizumab

TNF MAB for Crohn's

Methylcellulose

Bulk forming laxative

Mitrolax/FiberCon

Bulk forming laxative

Metamucil

Bulk forming laxative

Docusate Products

Stool emollients/softeners for constipation

Mineral Oil

Stool lubricant

Glycerin Suppositories

Stool lubricant

Aloe/Senna/Cascara

Stimulant laxative - anthraquinone derivative

Bisacodyl

Stimulant laxative - diphenylmethane derivative

Castor Oil

Stimulant laxative

Lubiprostone

Chloride channel activator for constipation

Methylnaltrexone

Opioid Receptor Antagonist for opioid constipation

Alvimopan

opioid receptor antagonist (CV toxicity) for opioid constipation

Zelnorm

Serotonin 5-HT4 agonist - induces peristalsis

Propulsid

Serotonin 5-HT4 agonist - induces peristalsis

Prucalopride

Serotonin 5-HT4 agonist - induces peristalsis w/o CV side effects

Diphenoxylate

opioid agonist and anti-diarrheal

Loperamide

opioid agonist and anti-diarrheal

Kaopectate

adsorbant for anti-diarrhea

Atropine

anticholinergic for anti-diarrhea

Bismuth salicylate and doxycycline

Traveler's diarrhea - acute and watery

Metronidazole

Giardia lamblia treatment

Ondansetron

5 HT3 antagonist and antiemetic pre-chemo/surgery

Granisetron

5 HT3 antagonist and antiemetic pre-chemo/surgery

Dolasetron

5 HT3 antagonist and antiemetic pre-chemo/surgery. high dose

Palonosetron

high affinity 5 HT3 antagonist and antiemetic pre-chemo/surgery. long HL

Dexamethasone/Methylprednisolone

corticosteroid and anti-emetic

Emend

NK1 antagonist and antiemetic used with 5HT3 ant and steroids

Prochlorperazine

Phenothiazine agent with antiemetic and sedative properties

Promethazine

Phenothiazine agent with antiemetic and sedative properties

Droperidol

Butyrophenone agent with antiemetic and sedative properties. QT elongation

Diphenhydramine

H1 antihistamine used for motion sickness prevention

Meclizine

H1 antihistamine used for motion sickness prev and vertigo

Hyoscine

anticholinergic for motion sickness prevention

Metoclopramide

Substituted benzamide and antiemetic

Trimethobenzamide

Substituted benzamide and antiemetic

Midazolam

Benzodiazepine and antiemetic for nervous vomit

Lorazepam

Benzodiazepine and antiemetic for nervous vomit

Dronabinol

cannabinoid and antiemetic

Nabilone

cannabinoid and antiemetic

Sodium bicarbonate

systemic antacid

Calcium carbonate

rapid acting systemic antacid

Magnesium salts

antacid Mg toxicity in renal failure

Aluminum salts

slow antacid

Simethicone

defoaming agents that increase surface tension of gas bubble

Gaviscon

foam barrier above gastric fluids

Cimetidine

H2 blocker that causes hormone imbalances

Ranitidine

H2 blocker

Nizatidine

H2 blocker with low FPM

Famotidine

H2 blocker that interacts with grapefruit juice

-prazole drugs

PPI

Sucralfate

Forms paste that defends ulcers from acids & decreases some drug abs

Misoprostol

PGE1 analog for prevention of NSAID ulcers (no pregnant)

Bismuth compounds

Coats ulcers