Shizo Drugs

100 cards·by Nari1212

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What are positive symptoms?

Delusions, Hallucination, Disorganized thinking, speech, behavior

What are the negative symptoms?

Alogia, Asocial, Anhedonia, Avolition

Positive Symptoms are in

Mesolimbic Pathway (Too much?)

Negative Symptoms are in

Mesocortical pathway (too little?)

FGD target

Positive

FGA MOA

D2 blockade

SGA MOA

Serotonin and D2 blockagde but Serotonin is more

FGA side effect

ESP, dyskenia

SGA side effect

metabolic side effects

FGA Notable Side Effetcs

Prolactin, EPS, Sedation, Weight Gain, Orthostatic, Anticholingeric,

FGA Serious Side effect

Priapism, Seizure, Jaundice. Agranulocysos, Neuropletic

Haldol caution

QTC prolongation

Adasuve

Doxapine (air/agitation)

Two FGA drug that comes in injectable

Halo and fluphenazine

Pines and Dones

D2 antagonist

Rips and Pips

D2 partial agnoist

SGA side effects

Weight gain, Insulin resistance, dyslipidemia. CArdiovascular disease, premature death

The two category B preg drugs are

Olanzapine and lurasidone

Clozapine when to use? (Ritsu)

Effective but not first line. Treatment resistent, refractory

BBW for Clozapine

Severe Neutropenia (REM), Ortho issue, Seizures, Heart issues

Monitor Meutropenia?

CBC. Base line. Weekly from start to 6 month. Every 2 week from 6~12 month. After one year it will be monthly

NOrmal ANC!

1500 or higher

ANC for BEN is

Higher than 1000

FazaClo

ODT of clozapine

Versacloz

Solution of Clozapine

Clozapine most side effect

Sedation, Ortho, weight gain

When do you want to use Risperidal?

irritability associated with autism spectrum disorder

Persersis

Resperidal in SQ

Risperdal Consta

Risperdal Side Effect

EPS (high doses) Hyperprolactinemia (dose-dependent) Orthostatic Hypotension, Weight gain, Insomnia

Risperdal Side Effect

EPS (high doses) Hyperprolactinemia (dose-dependent) Orthostatic Hypotension, Weight gain, Insomnia

invega

paliperidone

Which drug has OROS technology

Invega

Invega Sustenna

Given 8 days later (+4 days) IM routte

Invega Trinza

EVery 3 months

Zyprexa

olpanzapine

Symbyax

Olzapazine/fluoxetine

Which drug needs a higher dose for smokers

Olpazapine

Drug that has the most weight gain

Olanzapine

Zyprexa Relprevv BBW

PDSS and this one also needs REM

What are 4 meds to treat Mania

Lithiuj, VPA, SGD, CBZ

Acute Mania THerapeutic Level for Li

0.8~1.5

Maintenace dose for LI

0.6~1.2

Some side effect for Lithium

Polyuria, acne, hypothyroism, cardiac effect

What causes Li to go up?

NO ACEI HOLE

Decrease Li level

coffee, preg, theophyline, complicnace, potassium sparing diure

WHat is VPA therapeutic level

50~125

VPA BBW

HPPP

3 drugs that interact with VPA

warfarin, lamotrigine, phenytoin

CBZ therpaetic

4~12

3 DDI for CBZ

CUP inbhitor and sub and also anticonvulsant

lamotrigine level dreases when yo use

birthday control , Pheytoin, phenobartibal, CBZ, orla cto

Mydayis

Adderal ER morning

Dexedrine

Adderal morning 60 max

Adzenya

Adderal morning

Dyanavel

Adderall liquid

Evekeo

Adderal QM or BID

Concerta

meth has Oros

daytrana

meth patch

Adhansia

Sprinkle meth

cotempla

Grape meth

jornay

meth

Focali

dexmeth

Tenex

Gua

Intuniv

Gua

Kapvay

clonidine

ritalin

Meth

tyrosine

DA/NA

tryprophan

Serotonin

2 things that Zyprexa has

BW for PDSS (need to stay 3 hours after) and REM

Seroquel ADR

Sedation is high, Weight gain, insulin resisntae, ortho, ATC prolongation suicide

Monitor for Seroquel

Eye

Geodon

Ziprasidone (IM / capsule)

Ziprasidone ADR

ATC prolongation

Which drug has DRESS?

GEodon

symptoms for dress

Fever, skin eruption, looks like a really bad chicken oicks

Abilify Maintena

IM... PO overlaps.. 14 days after initial

Latuda

Lurasidone

CI for Latuda

CYP3A4 inducers

Latuda meal?

350 calories

Fanapt

iloperidone

ADR for Fanapt

Weight gain. Sedation. Ortho. QTC prolongation. EPS. Priapsim seizure, agranulo

Saphris

Asenapine (onlt sublingual)

Secuado

Path for of Asenapine

Rexulti

Brexpiprazole

VrayLar

Cariprazine

Nuplazid

Pimavanserin

Drug that is for Parkinson

Pimavanserin

Injectable that needs overlap

Consta, Maintena, Aristada

Emergency treatment

Halo + Dipeh + Lora

Acute Phase medications

Antipsych + catatonia

First timer go to Schizo meds

Ariprazole, Risperidone and ziprasidone

second timer? Do not use

clozapine

Top three weight gain Schizo meds

Clozapine Olanzapine seroquel (add riepseriodnne for DM)

Prolacin raising two drugs

RIsperidone and Paliperidone

Szirue causing schizo meds

Chlorpromazine and Clozapine

Two high ESP causing drugs

Risperidone and paliperidone

Ingrezza

Valbenzapine (VMAT)

Austedo

Deutetrabenzaine (VMAT)

How to manage NMS?

Dantrium, Bromocriptine or Amatadine