Pharm Week 1

Metyrosine

Indication: Hypertension MOA: Competitive inhibition of tyrosine hydroxylase -rate limiting step in the production of catecholamines

Reserpine

Indication: Hypertension MOA: Inhibits VMAT uptake of monoamines -VMATs transport monoamines into synaptic vesicles-keeps them from being

Bretylium

Indication: Ventricular Arrhythmia MOA: Inhibit action potential generation and calcium dependent synaptic vesicle fusion

Cocaine

Indication: Analgesia in surgery MOA: Blocks monoamine reuptake -re-uptake is the primary mode of terminating monoamines actions

Amphetamine or Ephedrine

Indication: Narcolepsy, ADHD MOA: Reverse monoamine reuptake transporters

Naloxone, Naltrexone

Indication: Opioid overdose or dependence MOA: Non- peptide blockers of opioid receptors in the CNS

SSRI

Indication: Depression/Anxiety MOA: Selective inhibition of serotonin reuptake transporter

ACE inhibitors (eg. lisinopril)

Indication: Hypertension MOA: Inhibit peptide cleavage of Angiotensin 1 to Angiotensin 2

Phenylephrine

Indication: Hypotension during surgery MOA: Direct agonist of adrenergic receptor

MOA inhibitors

Indication: Depression MOA: blockade of cytoplasmic metabolism of monoamines

L-DOPA

Indication: Parkinson's Disease MOA: precursor of dopamine, stimulates dopamine production

Carbidopa

Indication: Parkinson's Disease MOA: Blocks L-DOPA conversion to dopamine, does not cross BBB, so protects peripheral adrenergic neurons fr

Carbidopa

Indication: Parkinson's Disease MOA: Blocks L-DOPA conversion to dopamine, does not cross BBB, so protects peripheral adrenergic neurons fr

Tyramine

Indication: Ingested in diet, not therapeutic MOA: competes with NE for transport into synaptic vesicle